GH DNA RECOMBINANTE |
THE HYPOTHYROIDISM PURCHASED IN CHILD, INFANT AND YOUTH OLDER GROWTH MAY LEAD TO IMPROPER. CAIO JR, DR. ET CAIO H. DRA.
THE LOW HEIGHT (HEIGHT) CAN BE RESULTING IN CHILD, INFANT AND YOUTH FOR OLDER HYPOTHYROIDISM PURCHASED SUCH AS A LYMPHOCYTIC THYROIDITIS: PHYSIOLOGY-ENDOCRINOLOGY-NEUROENDOCRINOLOGY-GENETICS-ENDOCRINE-PEDIATRICS (SUBDIVISION OF ENDOCRINOLOGY): DR. JOÃO SANTOS CAIO JR. ET DRA. HENRIQUETA VERLANGIERI CAIO.
The features of hypothyroidism consist of a reduction in the rate of linear or longitudinal growth and short stature (height) especially in children, infant and juvenile older, associated with bone age and increased proportion SS/SI (upper and lower segments) delay for chronological age due to inadequate growth of the extremities.
Patients are apathetic, sleepy, unwilling to do anything, some difficulty thinking in general is not social and not give opinion, has constipation, bradycardia, roughness of the surface features and hair, hoarseness and delayed pubertal development, some decrease intellectual but not very compromising and reversible if treated. Intelligence is not affected in late-onset hypothyroidism, but the apathy and lethargy give that impression. Although weight gain is possible and frequent in cases of hypothyroidism, contrary to general belief, it is not extreme. The diagnosis of congenital hypothyroidism is established on the basis of neonatal screening tests. This standard procedure currently adopted worldwide is obtained a blood sample from the heel or umbilical cord at birth. Growth hormone-GH is closely linked to IGFBP-3 (insulin-like growth factor binding protein -3) in other words come to be interdependent which in turn the carrier of substances derived of thyroid. Name IGFBP-3; Synonyms IBP3; Function: Protein binding of IGF prolonging the half-life of the IGFs and have been shown to inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of the IGF with its cell surface receptors. Also shows antiproliferative and apoptotic effects mediated by IGF-independent TMEM219/IGFBP-3R your receiver. Therefore, short stature is a disaster and announced several substances interfere in this situation. Among the hormones, the most relevant for linear or longitudinal height growth hormone itself are growth hormone-GH and other hormones related to it IGF-1 and IGFBP-3, related to the thyroid TSH, T4, T3, adrenal (cortisol) and pubertal (LH, FSH, estradiol, testosterone). Some work stimulating and inhibiting other neonatal development, child and adolescent children, and the degree of importance of each differ by age.
The main causes of low hormonal linear primary or longitudinal height are hypothyroidism, growth deficiency, Cushing hormone (cortisol excess, or drugs from the body's own production) and untreated precocious puberty or early preventive. In other words, subjects with normal stature in the growth phase and all proportional parameters are a very strong hint of proper health and quality of healthy life.
Dr. João Santos Caio Jr.
Endocrinologia – Neuroendocrinologista
CRM 20611
Dra. Henriqueta V. Caio
Endocrinologista – Medicina Interna
CRM 28930
1. Recomenda-se para estas crianças, infantis, juvenis um ambiente de apoio no qual não seja permitido que crianças, infantis, juvenis de baixa estatura atuem como se fossem mais jovens do que sua idade cronológica ou não ocupem um lugar privilegiado na família...
http://hormoniocrescimentoadultos.blogspot.com
2. É de grande importância que a avaliação propedêutica clínico-laboratorial e instrumental seja muito detalhada e profunda para que o diagnóstico correto não seja comprometido...
http://longevidadefutura.blogspot.com
3. A baixa estatura é comumente percebida associada com desvantagem social e psicológica...
http://imcobesidade.blogspot.com
AUTORIZADO O USO DOS DIREITOS AUTORAIS COM CITAÇÃO
DOS AUTORES PROSPECTIVOS ET REFERÊNCIA BIBLIOGRÁFICA.
Referências Bibliográficas:
Caio Jr, João Santos, Dr.; Endocrinologista, Neuroendocrinologista, Caio,H. V., Dra. Endocrinologista, Medicina Interna – Van Der Häägen Brazil, São Paulo, Brasil; "Growth Hormone Deficiency" . Reino Unido Fundação Crescimento Infantil . Retirado 2009/01/16; "O atraso no crescimento (em crianças) - hormônio do crescimento humano (HGH)" (pdf). Instituto Nacional de Excelência Clínica. 2008-09-25 . Retirado 2009/01/16; James, William; Berger, Timothy; Elston, Dirk (2005). Doenças Andrews da pele: Dermatologia Clínica . (10th ed.). Saunders. ISBN 0-7216-2921-0; "O uso de hormônio de crescimento de substituição em doentes adultos com severa deficiência de hormônio do crescimento"; A Sociedade de Endocrinologia. 2000-10-01 . Retirado 2009/01/18; "Human Growth Hormone Deficiency" . HGH . Retirado 20 de janeiro de 2012; "hormônio do crescimento humano (somatropina) em adultos com deficiência de hormônio do crescimento" . Instituto Nacional de Excelência Clínica . 2006-07-01 . Retirado 2009/01/16; Rallison ML, Dobyns BM, Keating FR, et al. Occurrence and natural history of chronic lymphocytic thyroiditis in childhood. J Pediatr 1975; 86:675; de Vries L, Bulvik S, Phillip M. Chronic autoimmune thyroiditis in children and adolescents: at presentation and during long-term follow-up. Arch Dis Child 2009; 94:33; Ozer G, Yüksel B, Kozanoğlu M, et al. Growth and development of 280 hypothyroidic patients at diagnosis. Acta Paediatr Jpn 1995; 37:145; Purandare A, Co Ng L, Godil M, et al. Effect of hypothyroidism and its treatment on the IGF system in infants and children. J Pediatr Endocrinol Metab 2003; 16:35; Atchison JA, Lee PA, Albright AL. Reversible suprasellar pituitary mass secondary to hypothyroidism. JAMA 1989; 262:3175; Rallison ML, Dobyns BM, Meikle AW, et al. Natural history of thyroid abnormalities: prevalence, incidence, and regression of thyroid diseases in adolescents and young adults. Am J Med 1991; 91:363; Demirbilek H, Kandemir N, Gonc EN, et al. Hashimoto's thyroiditis in children and adolescents: a retrospective study on clinical, epidemiological and laboratory properties of the disease. J Pediatr Endocrinol Metab 2007; 20:1199; Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87:489; Radetti G, Gottardi E, Bona G, et al. The natural history of euthyroid Hashimoto's thyroiditis in children. J Pediatr 2006; 149:827; Radetti G, Maselli M, Buzi F, et al. The natural history of the normal/mild elevated TSH serum levels in children and adolescents with Hashimoto's thyroiditis and isolated hyperthyrotropinaemia: a 3-year follow-up. Clin Endocrinol (Oxf) 2012; 76:394.
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